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KMID : 0811720090130040295
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Korean Journal of Physiology & Pharmacology
2009 Volume.13 No. 4 p.295 ~ p.300
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The Inhibitory Effect of Quercetin-3-O-?-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats
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Min Young-Sil
Sohn Uy-Dong
Whang Wan-Kyunn
Sim Sang-Soo
Lee Se-Eun
Choi Byung-Chul
Hong Seung-Tae
Kim Hyun-Sik
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Abstract
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It was evaluated the inhibitory action of quercetin-3-O-?-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.
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KEYWORD
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Reflux esophagitis, Lipid peroxidation, Gastritis, Quercetin-3-O-?-D-glucuronopyranoside
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